客戶論文
2024年：
Shen J, Xie E, Shen S, Song Z, Li X, Wang F, Min J. Essentiality of SLC7A11-mediated nonessential amino acids in MASLD. Science Bulletin. 2024, Dec 15; 69(23): 3700-3716 Full text （影響因子18.8，中科院1區/JCR Q1區，鐵死亡-代謝組-代謝流-氨基酸定量）
Maremonti E, Brede DA, Kassaye YA, Zheng K, Lee Y, Salbu B, Teien HC. Dose rate dependent genotoxic and metabolic effects predict onset of impaired development and mortality in Atlantic salmon (S. salar) embryos exposed to chronic gamma radiation. Sci Total Environ. 2024 Dec 1; 954:176263. Full text （影響因子8.2，中科院1區/JCR Q1區，環境科學-三文魚-GC-MS非靶代謝組學）
Ovlyakulov B, Hu B-L, Kan H-Y, Guo Q, Li X-F, Fan H-H, Wu H-W, Wang J-Y, Zhang X , Zhu J-H. Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-induced mouse model of Parkinson's disease, Int Immunopharmacol. 2024, Sep 30; 139: 112715, Full text （影響因子4.8，中科院2區/JCR Q1區，神經遞質定量）
Shao T, Gao Q, Ma Y, Gu J, Yu Z. Hyperforin improves matrix stiffness induced nucleus pulposus inflammatory degeneration by activating mitochondrial fission. Int Immunopharmacol. 2024, Aug 20; 137: 112444. Full text （影響因子4.8，中科院2區/JCR Q1區，靶向糖代謝組定量）
Feng S, Wang D, Jin Y, Huang S, Liang T, Sun W, Du X, Zhuo L, Shan C, Zhang W, Jing T, Zhao S, Hong R, You L, Liu G, Chen L, Ye D, Li X, Yang Y. Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity. Cell Rep. 2024, Jun 25; 43(6): 114300. Full text （影響因子7.5，中科院1區/JCR Q1區，手性2-羥基戊二酸定量）
Wang Y, Shu H, Qu Y, Jin X, Liu J, Peng W, Wang L, Hao M, Xia M, Zhao Z, Dong K, Di Y, Tian M, Hao F, Xia C, Zhang W, Ba X, Feng Y, Wei M. PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer. EMBO J. 2024, Jun; 43(12): 2368-2396. Full text （影響因子6.9，中科院1區/JCR Q1區，腫瘤-中心碳代謝-代謝流）
Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, Liu L, Chen Y, Liu Y, Tan Q, Jiang Y, Yang W, Huang W, Weng C, Wu Q, Lu Y, Yuan H, Xiao Q, Chen AF, Xu Q, Billiar TR, Cai J. Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia. Cell Rep. 2024, May 28; 43(5): 114237. Full text （影響因子7.5，中科院1區/JCR Q1區，氧化心磷脂）
Wang Y, Cheng C, Lu Y, Lian Z, Liu Q, Xu Y, Li Y, Li H, Zhang L, Jiang X, Li B, Yu D. β-Catenin Activation Reprograms Ammonia Metabolism to Promote Senescence Resistance in Hepatocellular Carcinoma. Cancer Res. 2024, May 15; 84(10): 1643-1658. Full text （影響因子12.5，中科院1區/JCR Q1區，肝腫瘤-氨代謝流）
Xie W, Wang J, Tian S, Zhao H, Cao L, Liang Z, Yang J, Zhao Y, Wang B, Jiang F, Ma J. RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis. Oncogene. 2024, May; 43(19): 1463-1475. Full text （影響因子6.9，中科院1區/JCR Q1區，鐵死亡-輔酶Q10定量）
Chen KH, Feng J, Bodelier PLE, Yang Z, Huang Q, Delgado-Baquerizo M, Cai P, Tan W, Liu YR. Metabolic coupling between soil aerobic methanotrophs and denitrifiers in rice paddy fields. Nat Commun. 2024, Apr 24; 15(1): 3471. Full text（影響因子14.7，中科院1區/JCR Q1區，土壤微生物-甲烷代謝流-短鏈脂肪酸）
Guo X, Ji N, Guo Q, Wang M, Du H, Pan J, Xiao L, Gupta N, Feng Y, Xia N. Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii. Nat Commun. 2024, Apr 8; 15(1): 2999. Full text （影響因子14.7，中科院1區/JCR Q1區，寄生蟲-中心碳代謝-代謝流）
Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, Xue Y, Li Y, Chang Z, Li J, Chao T, Chen J, Cheng X, Gao X, Li X, Lu F, Chu Q, Wang W. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metab. 2024, Apr 2; 36(4): 822-838.e8. Full text （影響因子27.7，中科院1區/JCR Q1區，腫瘤免疫-脂肪酸降解代謝流-?；o酶A）
Han X, Wang D, Yang L, Wang N, Shen J, Wang J, Zhang L, Chen L, Gao S, Zong WX, Wang Y. Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. Proc Natl Acad Sci U S A. 2024, Mar 26;121(13): e2319429121. Full text （影響因子9.4，中科院1區/JCR Q1區，肺癌多胺代謝-谷氨酰胺代謝流）
Wang Y, Shi Y, Li W, Han X, Lin X, Liu D, Lin Y, Shen L. Knockdown of BRAWNIN minimally affect mitochondrial complex III assembly in human cells. Biochim Biophys Acta Mol Cell Res. 2024 Jan; 1871(1): 119601. Full text （影響因子4.6，中科院2區/JCR Q2區，代謝流）
2023年（因網站被黑，內容逐漸恢復中）：
Lu X, Hong J, Zhang J, Liu Q, Liao G, Shi Y, Tang H, Liu X. Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. Sci Total Environ. 2023 Dec 15; 904: 166688. Full text （影響因子9.8，中科院1區/JCR Q1區，環境醫學-色氨酸代謝物定量）
Deng Z, Li D, Yan X, Lan J, Han D, Fan K, Chang J, Ma Y. Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway. Life Sci. 2023, Sep 15; 329: 121984. Full text （影響因子6.1，中科院2區/JCR Q1區，神經遞質定量）
Tang L, Xu XH, Xu S, Liu Z, He Q, Li W, Sun J, Shuai W, Mao J, Zhao JY, Jin L. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Rep Med. 2023, May 16; 4(5): 101026. Full text （影響因子14.3，中科院1區/JCR Q1區，生育-非靶向代謝組-靶向定量-代謝流）
Zheng X, Zhang W, Hu Y, Zhao Z, Wu J, Zhang X, Hao F, Han J, Xu J, Hao W, Wang R, Tian M, Radak Z, Nakabeppu Y, Boldogh I, Ba X. DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation. Redox Biol. 2023, May;61:102634. Full text （影響因子11.4，中科院1區/JCR Q1區，8-Hydroxyguanine或8-oxoguanine定量）
Wang K, Da Y, Bi HR, Liu YH, Chen BQ, Wang M, Liu ZH, Nielsen J, Tan TW. A one-carbon chemicals conversion strategy to produce precursor of biofuels with Saccharomyces cerevisiae. Renew Ener. 2023, 208: 331-340. Full text （影響因子9，中科院2區/JCR Q1區，生物燃料-13C代謝流）
Song Y, Zheng K, Brede DA, Gomes T, Xie L, Kassaye Y, Salbu B, Tollefsen KE. Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation. Environ Sci Technol. 2023 Feb 28;57(8):3198-3205. Full text （影響因子11.4，中科院1區/JCR Q1區，環境-斑馬魚多組學-非靶向代謝組）
Lv Y, Tang W, Xu Y, Chang W, Zhang Z, Lin Q, Ji M, Feng Q, He G, Xu J. Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Int J Biol Sci. 2023 Feb 13; 19(4): 1284-1298. Full text （影響因子9.2，中科院2區/JCR Q1區，結腸癌-鐵死亡-氧化脂肪酸Oxylipins定量）
2022年（因網站被黑，內容逐漸恢復中）：
Li Y, Li B, Xu Y, Qian L, Xu T, Meng G, Li H, Wang Y, Zhang L, Jiang X, Liu Q, Xie Y, Cheng C, Sun B, Yu D. GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. Cancer Res. 2022. Sep 16; 82(18): 3223-3235. Full text （影響因子12.5，中科院1區/JCR Q1區，肝腫瘤-谷氨酰胺代謝流-碳氮雙標）
Wang Y, Gao X, Yang H. Integrated metabolomics of "big six" Escherichia coli on pea sprouts to organic acid treatments. Food Res Int. 2022 Jul;157:111354. Full text （影響因子7.425，中科院1區/JCR Q1區，農產品-抑菌-非靶向代謝組）
Shi Z, Gan G, Gao X, Chen F, Mi J. Kynurenine catabolic enzyme KMO regulates HCC growth. Clin Transl Med. 2022 Feb;12(2):e697. Full text （影響因子10.6，中科院1區/JCR Q1區，肝癌-色氨酸代謝）
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. Nat Commun. 2022 Sep 5;13(1): 5208. Full text （影響因子14.7，中科院1區/JCR Q1區，13C乳酸代謝流）
2021年（因網站被黑，內容逐漸恢復中）：
2020年：
GUO Wenzheng, LI Kaimi, LIN Shuhai*, Deng Jiong*, et al. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2020 . Full text （影響因子 9.727，JCR 一區，細胞-靶向代謝物定量）
HU Xiaoyu, GUO Jian, ZHAO Caijun, JIANG Peng, MAIMAI T, YANYI Li, CAO Yongguo, FU Yunhe*, ZHANG Naisheng*. The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice. ISME Journal. 2020,14(7):1897-1910. Full text （影響因子 9.180，JCR 一區，乳腺炎-腸道菌群-短鏈脂肪酸定量）
JIA Yaqian, YUAN Ziwen, ZHANG Xiaosong, DONG Jiaqi, LIU Xuenan, PENG Xiaoting, YAO Wanling, JI Peng, WEI Yanming, HUA Yongli*. Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota. Journal of Ethnopharmacology. 2020, 255: 112775. Full text（影響因子 3.690，JCR 二區，小鼠-膽汁酸絕對定量）
WANG Pan, GAO jianpeng, KE Weixin, WANG Jing, LI Daotong, LIU Ruolin, JIA Yan, WANG Xuehua, CHEN Xin, CHEN Fang, HU Xiaosong*. Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota. Free Radic Biol Med. 2020,156: 83-98. Full text（影響因子 6.170，JCR 一區，高脂飲食小鼠腸道菌群與白藜蘆醇-代謝組與定量）
FU Yi, WANG Dongdong, HE Wei*, ZHANG Jianmin*, et al. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma. Neuro-oncology, 2020, 22(2): 240-252. Full text（影響因子 10.247，JCR 一區，神經膠質母細胞瘤-代謝流）
GAO Jing, WEI Tong, HUANG Chenglin, SUN Mengwei, SHEN Weili*. Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition. FASEB Journal, 2020, 34(12): 16645-16661. Full text （影響因子 4.966，JCR 一區，高血壓-細胞-代謝流）
QIU Yixuan, SHEN Linyan, NING Guang* (中國工程院院士), GU Yanyun*, et al. The glucose-lowering effects of α-glucosidase inhibitor require a bile acid signal in mice. Diabetologia. 2020, 63(5): 1002-1016. Full text （影響因子 7.518，JCR 一區，2型糖尿病-腸道菌群-膽汁酸定量）
SUN Silei, ZHAO Bing, CHEN Erzhen*, MAO Enqiao*. TUDCA ameliorates liver injury via activation of SIRT1-FXR signaling in a rat hemorrhagic shock model. Shock. 2020, 53(2): 217-222. Full text （影響因子 2.960，JCR 二區，鼠失血性休克-肝損傷-膽汁酸定量）
FANG Sijie, ZHANG Shuo, HUANG Yazhuo, ZHOU Huifang*, FAN Xianqun*, et al. Evidence for associations between Th1/Th17 "Hybrid" phenotype and altered lipometabolism in very severe graves orbitopathy. Journal of Clinical endocrinology & Metabolism. 2020, 105(6): dgaa124. Full text （影響因子 5.493，JCR 一區，眼病-臨床血清-脂質組學）
CHEN Diling, GUO Yinrui, XIE Yizhen*, WU Qingping*, et al. Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis. Journal of Functional Foods. 2020, 65: 103639. Full text （影響因子 3.701，JCR 二區，糞便-代謝組學）
FANG Xuexian, CAI Zhaoxian, MIN Junxia*, WANG Fudi*, et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research. 2020, 127(4): 486-501. Full text （影響因子 14.467，JCR 一區，谷胱甘肽、半胱氨酸等靶向代謝組定量）
WANG Xifan, YANG Songtao, Ehrlich Stanislav Dusko*, REN Fazheng*, YU Zhengquan*, et al. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut. 2020, 69(12): 2131-2142. Full text （影響因子 19.819，JCR 一區，腎衰竭-尿毒癥毒素-腸道微生物腸道菌群-糞便膽汁酸代謝物定量）
Lei C, Chen J, Li H, Fan T, Zheng X, Wang H, Zhang N, Liu Y, Luo X, Wang J, Wang A. Role of the Mitochondrial Citrate-malate Shuttle in Hras12V-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis. Metabolites. 2020, 10(5): 193. Full text（JCR 二區，肝腫瘤-代謝組與中心碳代謝代謝流）
LIANG Xiaohan, CUI Jianmin, SHEN Bang*, et al. Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma. Journal of Biological Chemistry. 2020, 295(22): 7743-7752. Full text （影響因子 4.238，弓形蟲-脂肪酸代謝流）
Zhao M, Hou Y, Du YE, Yang L, Qin Y, Peng M, Liu S, Wan X, Qiao Y, Zeng H, Cui X, Teng Y, Liu M. Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism. Cancer Lett. 2020 May 28; 478: 8-21. Full text （影響因子 7.36，一碳代謝四氫葉酸代謝流）
LIU Fei, ZHANG Hui, DING Ling, XIANG Yong*, et al. REVERSAL OF RDO5 1, a Homolog of rice seed dormancy 4, interacts with bHLH57 and controls ABA biosynthesis and seed dormancy in Arabidopsis. Plant Cell, 2020, 32(6): 1933-1948. Full text （影響因子 8.631，JCR 一區，擬南芥-植物激素定量）
DING Xisheng, SUN Wen, DAI Lili, LIU Chunsheng, SUN Qian, WANG Jianghua, ZHANG Panwei, LI Kun, YU Liqin*.Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Environmental Pollution, 2020, 267: 115305. Full text （影響因子 6.791，JCR 一區，斑馬魚-神經遞質定量）
ZHU Mingzhe, LI Meng, ZHANG Li*, JI Gaung*, et al. Metabolomic analysis identifies glycometabolism pathways as potential targets of Qianggan Extract in hyperglycemia rats. Frontiers in Pharmacology, 2020, 11: 671. Full text （影響因子 4.225，JCR 一區，中藥藥理-代謝組）
DONG Zhen, LI Ruoshui, XU Lei, XIN Kaiyue, SUN Aijun*, GE Junbo* (中國工程院院士), et al. Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. Immunology, 2020, 160(2): 183-197. Full text （影響因子 5.016，JCR 二區，巨噬細胞-代謝流）
CHEN Lingling, XIA Fangsha, MAO Peisheng*, et al. Metabolomic analyses of alfalfa (Medicago sativa L. cv. ‘Aohan’) reproductive organs under boron deficiency and surplus conditions. Ecotoxicology and Environmental Safety, 2020, 202: 111011. Full text （影響因子 4.872，JCR 一區，苜蓿-代謝組學）
2019：
中國醫學科學院北京協和醫學院-病毒與細胞-代謝組&代謝物定量
LIU Yang, YOU Yuling, CAO Xuetao* (中國工程院院士), et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science, 2019, 365: 1171-1176. Full text （影響因子 41.845，JCR 一區）
復旦大學附屬華山醫院-肝癌細胞-乙酰輔酶A定量
LU Ming*, ZHU Wen-Wei, QIN Lun-Xiu*, et al. ACOT12-dependent alteration of acetyl-CoA drives hepatocellular carcinoma metastasis by epigenetic induction of epithelial-mesenchymal transition. Cell Metabolism, 2019, 29: 886-900. Full text （影響因子 21.567，JCR 一區）
河南大學基礎醫學院-納米材料毒性-動物血清-代謝組學
YANG Yanjie, LV Shuangyu*, JI Shaoping*, et al. Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice. International Journal of Nanomedicine, 2019, 14: 6297-6311. Full text （影響因子 5.115，JCR 二區）
中國科學院上海生物化學與細胞生物學研究所-神經-惡性膠質瘤細胞-糖代謝定量
WANG Xiongjun, LIU Ruilong, LI Guohui*, YANG Weiwei*, et al. α-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor development. Molecular Cell, 2019, 76(1): 148-162.e7 Full text （影響因子 15.584，JCR 一區）
中國農業大學食品科學與營養工程學院-肥胖與代謝綜合征-中藥生姜-糖代謝定量
WANG Jing, LI Daotong, WANG Pan, HU Xiaosong, CHEN Fang. Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice. Journal of Nutritional Biochemistry. 2019, 70: 105-115. Full text （影響因子 4.873，JCR 一區）
昆明理工大學-靈長類動物(食蟹猴)-血與腦脊液-神經遞質定量
ZHANG Bo*, ZHOU Zhigang, JI Weizhi (中國科學院院士), CHEN Yongchang*, et al. Social‐valence‐related increased attention in rett syndrome cynomolgus monkeys: An eye‐tracking study. Autism Research, 2019, 12: 1585–1597. Full text （影響因子 3.727，JCR 三區）
上海交通大學醫學院-肥胖相關的胰島素抵抗-支鏈氨基酸與支鏈羰酸定量
ZHOU Meiyi, SHAO Jing, WU Cheng-Yang, SHU Le, SUN Haipeng*, et al. Targeting BCAA catabolism to treat obesity-associated insulin resistance. Diabetes. 2019, 68(9): 1730-1746. Full text （影響因子 7.72，JCR 一區）
上海中醫藥大學附屬龍華醫院-中藥-動物糖尿病-血清組織糞便-代謝組學
LI Meng, DANG Yanqi, ZHANG Li*, JI Guang*, et al. Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. Scientific Reports. 2019, 9(1): 8003. Full text （影響因子 3.998，JCR 一區）
上海東方肝膽醫院-臨床-肝癌組織-代謝物定量
LIU Jiao, JIANG Jinhua, WANG Hailin*, HE Yufei*, WANG Hongyang*, et al. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, 2019, 9(1): 196-208. Full text （影響因子 14.679，JCR 一區）
上海中醫藥大學李后開教授-腸道菌群-血清-GC-MS非靶向代謝組學
GU Yu, LIU Can, ZHANG Weidong*, LI Houkai*, et al. Metabolic and gut microbial characterization of obesity-prone mice under a high-fat diet. Journal of Proteome Research, 2019, 18(4): 1703-1714. Full text （影響因子 4.074，JCR 一區）
中國科學院上海生物化學與細胞生物學研究所-腫瘤細胞-代謝流
LIU Ruilong, LI Wenfeng, YANG Weiwei*, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nature Communications, 2019, 10: 991. Full text （影響因子 12.121，JCR 一區）
第四軍醫大學西京醫院-李霞-張耀-腫瘤細胞-代謝流
Zhang Y, Lv W, Li Q, Wang Q, Ru Y, Xiong X, Yan F, Pan T, Lin W, Li X. IDH2 compensates for IDH1 mutation to maintain cell survival under hypoxic conditions in IDH1?mutant tumor cells. Mol Med Rep. 2019 Aug;20(2):1893-1900. Full text （影響因子 3.37，JCR 二區）
華中農業大學-寄生蟲機制-代謝流 美國微生物協會期刊
XIA Ningbo, YE Shu, LIANG Xiaohan, SHEN Bang*, et al. Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii. mBio, 2019, 10: e00898-19. Full text （影響因子 6.784，JCR 一區）
中國農業大學-藥物毒理學-動物組織-脂質組
YANG Xuan, XU Wentao, HE Xiaoyun*, et al. Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal lipotoxicity. FASEB Journal, 2019, 33(2): 2212-2227. Full text （影響因子 4.966，JCR 一區）
中國醫學科學院病原生物學研究所-病毒(寨卡病毒)-細胞和組織-脂質組學
ZHOU Jia, CHI Xiaojing, YANG Wei*, et al. Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis. Science Advances. 2019, 5(10): eaax7142. Full text （影響因子 13.116，JCR 一區）
2018：
北京生命科學研究所北京蛋白質組研究中心-肝癌-細胞-代謝組與脂質組學
CAI Mengjiao, SUN Xiao, HAN Suxia*, CHEN Huan*, ZHANG Pumin*, et al. Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells. Cancer Letters, 2018, 421: 82-93. Full text （影響因子 7.360，JCR 一區）
中南大學湘雅醫院-肺癌-細胞-代謝流
LI Jiangjiang, HE Ya, CAO Ya*, et al. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Theranostics, 2018, 8(15): 4050-4061. Full text （影響因子 8.579，JCR 一區）
復旦大學附屬上海公共衛生臨床中心盧洪洲-艾滋病-血漿-色氨酸代謝物定量
CHEN Jun, XUN Jingna, LU Hongzhou*, et al. Plasma indoleamine 2, 3-dioxygenase activity is associated with the size of the human immunodeficiency virus reservoir in patients receiving antiretroviral therapy. Clinical Infectious Diseases, 2018, 68(8): 1274-1281. Full text （影響因子 8.313，JCR 一區）
上海交通大學醫學院附屬瑞金醫院-2型糖尿病-抗生素-血漿-糞便-腸道菌群-短鏈脂肪酸-膽汁酸定量
FU Lihong, QIU Yixuan, NING Guang (中國工程院院士), NIE Aifang*, GU Yanyun*, et al. The delayed effects of antibiotics in type 2 diabetes, friend or foe? Journal of Endocrinology, 2018, 238(2): 137-149. Full text （影響因子 4.041，JCR 一區）
暨南大學生物轉化醫學研究院-高云飛團隊-代謝流
XIA Xichun, ZHOU Wei, GUO Chengbin, FU Zhen, ZHU Leqing, LI Peng, XU Yan, ZHENG Liangyan, ZHANG Hua, SHAN Changliang, GAO Yunfei*. Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion. Front Oncol. 2018, 8: 632. Full text （影響因子 4.848，JCR 二區）
中國科學院上海生物化學與細胞生物學研究所-楊巍維團隊-巨噬細胞-代謝流
ZHANG Yajuan, YU Guanzhen, LI Guohui*, YANG Weiwei*, et al. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Molecular Cell, 2018, 71(2): 201-215.e7 Full text （影響因子 15.584，JCR 一區）
四川農業大學-植物組織(玉米幼苗)-缺磷-基因組-非靶向代謝組學
LUO Bowen, MA Peng, GAO Shibin*, et al. Metabolite profiling and genome-wide association studies reveal response mechanisms of phosphorus deficiency in maize seedling. Plant Journal, 2018, 97(5): 947–969. Full text （影響因子 6.141，JCR 一區）
西北農林科技大學-動物(雞)-非酒精性脂肪肝-脂代謝-葉酸-非靶向代謝組
LIU Yanli, SHEN Jing, YANG Xiaojun*, et al. Folic acid reduced triglycerides deposition in primary chicken hepatocytes. Journal of Agricultural and Food Chemistry, 2018, 66: 13162-13172. Full text （影響因子 4.192，JCR 一區）
中國農科院植物保護研究所-貝萊斯芽孢桿菌-非靶向代謝組
WANG Junqiang, GUO Rongjun*, LI Shidong*, et al. Insight in o the surfactin production of Bacillus velezensis B006 through metabolomics analysis. Journal of Industrial Microbiology & Biotechnology, 2018, 45(12):1033-1044. Full text （影響因子 1.681，JCR 二區）
上海交通大學醫學院附屬仁濟醫院-結腸癌-細胞-代謝組學&代謝流
WANG Yun-Qian, WANG Hao-Lian, CHEN Ying-Xuan*, et al. Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner. Nature Communications. 2018, 9: 545. Full text （影響因子 12.121，JCR 一區）
中國農業大學-腸道微生物(腸道菌群)-糞便-短鏈脂肪酸-芳香類物質-非靶向代謝組&靶向定量(芳香類物質定量)
LI Daotong, WANG Pan, CHEN Fang*, et al. Gut microbiota promotes production of aromatic metabolites through degradation of barley leaf fiber. Journal of Nutritional Biochemistry, 2018, 58: 49-58. Full text （影響因子 4.873，JCR 一區）
華中農業大學水產學院-環境污染-神經毒性-斑馬魚-神經遞質定量
GUO Xiaochun, ZHANG Shengnan, LU Shaoyong*, ZHENG Binghui, XIE Ping, CHEN Jun, LI Guangyu, LIU Chunsheng, WU Qin, CHENGE Houcheng, SANG Nan. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos. Environmental Pollution, 2018, 241: 1018-1026. Full text （影響因子 6.791，JCR 一區）
華中農業大學-寄生蟲-細胞-代謝流
XIA Ningbo, YANG Jichao, SHEN Bang*, et al. Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo. Cellular Microbiology, 2018, 20(1): e12794. Full text （影響因子 3.430，JCR 二區）
西北農林科技大學動物科技學院-雞-肝臟-非靶向代謝組學
WU Shengru, LIU Yanli, YANG Xiaojun*, et al. Hepatic metabolomic profiling changes along with postnatal liver maturation in breeder roosters. Biology Open, 2018, 7(1): bio028944. Full text （影響因子 2.029，JCR 三區）
2017：
華南農業大學-病毒-細胞-非靶向代謝組學 Front. Microbiol. IF=4.235
GOU Hongchao, ZHAO Mingqiu, CHEN Jinding*, et al. Metabolic profiles in cell lines infected with classical swine fever virus. Frontiers in Microbiology, 2017, 8: 691. Full text
上海海洋大學-魚組織-靶向代謝物(視黃酸)定量 Nat. Genet. IF= 27.603
SAHO Changwei, BAO Baolong, Xie ZY, POWER Deborah M*, WANG Qingyin*, SCHARTL Manfred*, CHEN Songlin*, et al. The genome and transcriptome of Japanese flounder provide insights in o flatfish asymmetry. Nature Genetics, 2017, 49: 119-124. Full text
上海交通大學醫學院附屬瑞金醫院-臨床2型糖尿病-腸道菌群-血漿膽汁酸定量 Nature Communications IF=12.121
GU Yanyun, WANG Xiaokai, Kristiansen Karsten*, NING Guang*, WANG Weiqing*, et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nature Communications, 2017, 8: 1785. Full text
上海交通大學醫學院附屬瑞金醫院-肥胖-腸道菌群-血清-非靶向代謝組-靶向代謝物定量 Nature Medicine IF=36.130
LIU Ruixin, HONG Jie, NING Guang* (中國工程院院士), Kristiansen Karsten*, WANG Weiqing*, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine, 2017, 23: 859-868. Full text
上海交通大學醫學院附屬瑞金醫院-肥胖-細胞-靶向代謝物定量 Endocrine IF=3.235
NING Tinglu, ZOU Yaoyu, WANG Jiqiu*, NING Guang* (中國工程院院士), et al. Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine, 2017, 56(2): 366-378. Full text
上海中醫藥大學-腸道菌群-血清-非靶向代謝組-靶向定量（膽汁酸）Journal of proteome research IF=4.074
HE Xuyun, ZHENG Ningning, HE Jiaojiao, LIU Can, FENG Jing, JIA Wei*, LI Houkai*. Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice. J Proteome Res. 2017,16(5): 1900-1910. Full text
上海中醫藥大學-中藥毒性研究-尿液-非靶向代謝組學
HU Xueqing, SHEN Jiaying, PU Xueyan, ZHENG Ningning, DENG Zhongping, ZHANG Zean, LI Houkai*. Urinary time- or dose-dependent metabolic biomarkers of aristolochic acid-induced nephrotoxicity in rats. Toxicological Sciences. 2017, 156(1): 123-132. Full text （影響因子 3.703，JCR 一區）
華中農業大學水產學院-微囊藻毒素-神經毒性-斑馬魚-神經遞質定量
WU Qin, YAN Wei, CHEN Houcheng, LIU Chunsheng, HUNG Tien-Chieh, GUO Xiaochun, LI Guangyu*. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environmental Pollution, 2017, 231: 471-478. Full text （影響因子 6.971，JCR 一區）
中國科學院-食管癌-靶向定量-色氨酸代謝 Biochem Biophys Res Commun. IF=2.985
CHENG Jing, JIN Hai, ZHENG Guangyong*, GAO Xianfu*. Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2017, 486(3): 781-787. Full text
2016：
江南大學-菌微生物大腸桿-Plos One-GC-MS非靶向 IF 3.234
Liu LN, Duan XG, Wu J. L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway. Plos One, 2016.
江南大學-菌微生物大腸桿-Journal of Biotechnology-GC-MS非靶向 IF 3.163
Liu LN, Duan XG, Wu J.Modulating the direction of carbon flow in Escherichia coli to improvel-tryptophan production by inactivating the global regulator FruR. Journal of Biotechnology, 2016.
上海中醫藥大學-高血脂癥藥物治療研究-大鼠血清肝臟糞便-Journal of Tranlational Medicine-GC-MS非靶向 IF 4.098
Li M, Shu XB, Ji G, et al. Integrative analysis of metabolome and gut microbiota in dietinduced hyperlipidemic rats treated with berberine compounds. Journal of Tranlational Medicine, 2016.
揚州大學-腸道菌群-血漿-Scientific Reports GC-MS靶向（短鏈脂肪酸） IF 4.011
Liu L, Zhao X, Gong DQ, et al. Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Scientific Reports, 2016.
